Mechanobiology Laboratory

• subjectSkills

  By working at the interface between engineering and biology, we investigate the spatial and temporal effects of various micro-environmental factors, including three-dimensionality of the cell environment and isotropy of the applied forces, on stem cell renewal and differentiation.

   

  Our skills in 3D:

  • Static/perfused culture of adherent cells
  • Cell biochemical assays
  • Histology on pellets and tissue
  • Fluorescence imaging
  • Transfection and transduction
  • Tissue engineering
  • Microbiology
  • Multiphysics computational modelling

• subjectResearch activities

  We develop frontier tools for cell modelling, including microengineered stem cell niches, microfluidic bioreactors and miniaturised windows for intravital imaging. Our long-term goal is to develop the potential of engineered tissue-equivalents and organoids in in biological research applied to cell modelling, drug discovery and regenerative medicine.

   

  Fundede research projects:

  • Synthetic niche substrates for mesenchymal stem cell culture – ERC-funded projects NICHOID and NICHOIDS
  • Miniaturised optically-accessible bioreactors – ERC-funded project MOAB 
  • Miniaturised windows for intravital imaging – MIUR-funded project BEYOND

• peopleTemporary Research Fellow

  CHIARA MARTINELLI

• peoplePhD

  ALBERTO BOCCONI

  ALESSANDRA NARDINI

  PAOLO RITTER

• linkKeywords

  Artificial Organs

  Biobased materials

  Biofluid-dynamics

  Biomaterials

  Biomechanics

  Biomedical Engineering

  Biomedicine

  Biomimetic

  Bioreactor for Tissue Engineering

  Biotechnologies

  Cell Culture

  Cell scaffold

  Drug Delivery

  Fluorescence microscopy

  Gene Delivery

  Health

  Intermolecular Interactions

  Lab on a Chip

  Mechanobiology

  Microfluidics

  Molecular dynamics simulations

  Multi-Scale Modeling

  Nanomaterials

  Nanomedicine

  Nanoparticles

  Regenerative Medicine Scaffolds

  Stem cell

  Tissue Engineering Scaffolds

  Tissue Mechanics

  Transport phenomena