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Emanuela Jacchetti graduated in Physics at the University of Milan and completed her PhD. in Physics, Astrophysics and Applied Physics, at the same University. During her career, she worked in various cities and Research Institutes such as the Institute of Biophysics-CNR in Genoa and Pisa, the Advanced Biotechnology Center in Genoa, the Scuola Normale Superiore at Pisa and the Experimental Imaging Center of the San Raffaele Hospital in Milan.

Since 2016 she has been working at the Politecnico di Milano on the Prof. Raimondi ERC-CoG project: "NICHOID - Mechanobiology of nuclear import of transcription factors modelled within a niche of bioengineered stem cells", first as Post Doc and from 2018 as fixed-term junior researcher.
Now she is assistant professor at Politecnico di Milano to work on the Prof. Manuela Raimondi’s ERC Consolidator Grant: “NICHOID - Mechanobiology of nuclear import of transcription factors modelled within a bioengineered stem cell niche”. Her main interests are cell mechanics and nuclear mechanotransduction and their visualization with optical microscopy techniques.

Her research is focalized on the mechanobiology, such as the mechanical process, that govern cell morphology and functions (like migration or stem cell differentiation), as well as on the protein diffusion and localization. She has a strong experience in the fields of innovative cell scaffold and fluorescence microscopy.

Selected pubblications

• Regulation of nucleocytoplasmic translocation in mesenchymal stem cells: characterization and methods for investigation. Boeri L, Albani D, Raimondi MT#, Jacchetti E#. Biophys Rev (2019) 11(5): 817–831
• The Effect of Cell Morphology on the Permeability of the Nuclear Envelope to Diffusive Factors. García-González A*, Jacchetti E* et al. Front Physiol. 2018 Jul 13;9:925
• Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity. Loffreda A*, Jacchetti E* et al. Nat Commun. 2017 Aug 22;8(1):313
• Temperature and pressure effects on GFP mutants: explaining spectral changes by molecular dynamics simulations and TD-DFT calculations. Jacchetti E et al. Phys Chem Chem Phys. 2016. 14;18(18):12828-38
• Microstructured polydimethylsiloxane membranes for peripheral nerve regeneration. Jacchetti E et al. Microelectronics Engeenering, 2014,124: 26-29
• Wharton’s Jelly human Mesenchymal Stem Cell contact guidance by noisy nanograting. Jacchetti E et al. Scientific Reports. 2014 23;4:3830

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