Through numerical simulations, the research activities are aimed at the study, of the mechanical, fluid dynamic, mass transport and thermal behavior of implantable prosthetic devices and their interaction with biological tissues. Our studies are performed in the context of in silico medicine, with particular emphasis on both the verification and validation of developed models and on the quantification of uncertainties. Our skills are aimed at multiphysics and multiscale problems for the study of cardiac and vascular mechanics, spinal surgery and orthopedic applications, based on clinical data and images, and on experimental measurements. We develop constitutive models for biological materials and prosthetic materials. We are experts in fluid-structure simulations (FSI) and we have experience in the segmentation of clinical images for patient-specific anatomical reconstructions.
One of the pillars of the COMPBIOMECH-LaBS research activities is the modeling and simulation of spinal, orthopedic and osteosynthesis devices. This research area is closely linked to the experimental verification and certification of the devices themselves.
Furthermore, our research activities include the modeling and simulation of the cardio and neuro-vascular system and of devices used for their treatment: arterial and venous vessels, endoprostheses such as percutaneous heart valves, coronary and peripheral stents, endografts, and stent-retrieval for the removal of brain thrombi. Devices made of shape memory alloys and with 3D printing techniques are widely studied. Electrophysiology of the heart is also simulated with particular attention to ventricular and atrial arrhythmias, in addition to the multiphysical nature of the electro-fluid-mechanical interactions of the heart.