Person details

phone +39 02 2399 3197
email mattia.sponchioni@polimi.it
keyboard_voice Voip Call
web Polimi Personal Page
group CFALab


  • 21.12.2018     PhD (cum laude) in Industrial Chemistry and Chemical Engineering
    Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano
    PhD Supervisor Prof. Davide Moscatelli
    PhD thesis title: “Biodegradable Thermo-Responsive Polymers for Drug Delivery and Tissue Engineering”
  • 28.07.2015     Master of Science in Chemical Engineering (grade 110/110 cum laude)
    Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano
    Master thesis title: “Sintesi e caratterizzazione di una nuova classe di polimeri thermoresponsive a base di PEG per applicazioni biomediche”
  • 22.07.2013     Bachelor of Science in Chemical Engineering (grade 110/110 cum laude)
    Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano

Current Positions

  • 2020 – present     Assistant Professor (RTDA)
    Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano
  • 2019 – present     Volume Editor for the Volume 57 of the serial “Advances in Chemical Engineering” published by Elsevier. The Volume is titled “Advances in Polymer Reaction Engineering” and represents a collection, edited and cured by the Volume Editor, of contributions from academic as well as industrial experts in the field. Publication of the Volume is scheduled for July 2020.
  • 2019 – present     Member of the American Chemical Society

Previous Positions

  • 2019     Postdoctoral Researcher
    Department of Chemistry and Applied Biosciences, ETH Zurich
    Supervisor: Prof. Massimo Morbidelli
    Topic: Purification of monoclonal antibodies by continuous counter-current chromatography
  • 2018 – 2019     Research Fellow
    Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano
    Topic: Synthesis of thermo-responsive cell scaffold materials for the controlled differentiation of human pluripotent stem cells
  • 2017     Visiting Research Student
    Dainton Building, Department of Chemistry, University of Sheffield, UK
    Supervisor: Prof. Steven P. Armes
    Topic: Synthesis and characterization of thermo-responsive worm gels for cell housing
  • 2015     Internship
    Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano

Research Activity

The research interests of Mattia Sponchioni lay mainly in the field of Polymer Reaction Engineering and colloidal dispersions primarily for biomedical and oil and gas applications.

The major research area of Mattia Sponchioni is that of thermo-responsive polymers. These are promising materials able to reversibly change their physical status in response to temperature stimuli. This behavior can be advantageously exploited for the realization of engineered nanoparticles able to load hydrophobic therapeutics and modulate their release in vivo in response to thermal stimulation. Another suggestive application is the development of materials able to undergo a sol-gel transition once injected into the body. This represents an innovative approach towards the localized delivery of therapeutics from gel scaffolds with minimal pain and risk for the patient during the inoculation of the delivery scaffold.

Mattia is also active in the field of wastewater treatment and bioremediation. Water pollution is nowadays an extremely impellent topic, due to the shrinkage of freshwater resources that impose recycle and purification as the sole solutions to the problem. Mattia developed Polymer Flakes able to capture and remove pollutants dispersed in water thus granting a safe and clean resource. Polymer Flakes have been awarded in 2019 with the Switch2Product as an innovative solution with disruptive potential on the market.

Mattia is also active in the field of continuous chromatographic purification of biotherapeutics. In particular, continuous chromatography is coming to the forefront for the efficient purification of therapeutic proteins, monoclonal antibodies and oligonucleotides reaching the purity standards required by the regulatory agencies. 

Selected Publications

  • M. Sponchioni, C.T. O’Brien, C. Borchers, E. Wang, M.N. Rivolta, N.J.W. Penfold, I. Canton ad S.P. Armes, “Probing the Mechanism for Hydrogel-Based Stasis Induction in Human Pluripotent Stem Cells: Is the Chemical Functionality of the Hydrogel Important?”, Chemical Science, 11 (1), 2020, pp. 232-240.
  • N. Manfredini, E. Scibona, M. Morbidelli, D. Moscatelli, M. Sponchioni*, “110th Anniversary: Tailoring the Composition of Non-Fouling Copolymers for Readily Coating Tissue Culture Polystyrene Surfaces”, 2019, Industrial & Engineering Chemistry Research, 58 (49), 2019, pp. 22290-22298.
  • M. Sponchioni, P. Rodrigues Bassam, P. Arosio, D. Moscatelli and U. Capasso Palmiero, “Biodegradable Zwitterionic Nanoparticles with Tunable UCST-type Phase Separation under Physiological Conditions”, Nanoscale, 11 (35), 2019, pp. 16582-16591.
  • M.Sponchioni*, U. Capasso Palmiero, D. Moscatelli, “Thermo-Responsive Polymers: Applications of Smart Materials in Drug Delivery and Tissue Engineering”, Materials Science and Engineering C, 102, 2019, pp. 589-605.
  • M. Sponchioni, U. Capasso Palmiero, N. Manfredini, D. Moscatelli, “RAFT Copolymerization of Oppositely Charged Monomers and its Use to Tailor the Properties of Nonfouling Polyampholytes with an UCST Behaviour”, Reaction Chemistry and Engineering, 4 (2), 2019, pp. 436-446.
  • R. Ferrari, M. Sponchioni*, M. Morbidelli, D. Moscatelli, “Polymer Nanoparticles for the Intravenous Delivery of Anticancer Drugs: the Checkpoints on the Road from the Synthesis to Clinical Translation”, Nanoscale, 10 (48), 2018, pp. 22701-22719.
  • M. Sponchioni, U. Capasso Palmiero, Davide Moscatelli, “HPMA-PEG Surfmers and their Use in Stabilizing Fully Biodegradable Polymer Nanoparticles”, Macromolecular Chemistry and Physics, 218 (23), 2017, Article number 1700380.
  • M. Sponchioni, L. Morosi, M. Lupi, U. Capasso Palmiero, “Poly(HPMA)-Based Copolymers with Biodegradable Side Chains Able to Self Assemble into Nanoparticles”, RSC Advances, 7 (80), 2017, pp. 50981-50992.
  • D. Moscatelli, M. Sponchioni, “Chapter 12: Bioresorbable Polymer Nanoparticles in the Medical and Pharmaceutical Fields: a Promising Field”, in Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine, 2016, pp. 265-283, 1st Edition, Elsevier.
  • M. Sponchioni, R. Ferrari, L. Morosi, D. Moscatelli, “Influence of the Polymer Structure over Self-Assembly and Thermo-Responsive Properties: the Case of PEG-b-PCL Grafted Copolymers via a Combination of RAFT and ROP”, Journal of Polymer Science, Part A: Polymer Chemistry, 54 (18), 2016, pp. 2919-2931.