CONTACTS

TEACHING

PUBLICATIONS

  

  

RESEARCH

PROFILE

Francesca Baldelli Bombelli is associate Professor in Chemistry at the Politecnico di Milano. She currently works at the Department of Chemistry, Materials and Chemical Engineering in the SupraBioNanoLab (www.suprabionano.eu). She has been Group Leader at the European Centre of Nanomedicine in 2013-2015. In 2011-2014 she has been Lecturer in Nanotechnology and Colloid Science at the School of Pharmacy, UEA, Norwich, UK. She has been Post-Doc researcher: 2009-2011 at CBNI, University College of Dublin, Dublin, Ireland; 2006-2009 at the University of Florence; 2004-2006 at Chalmers University, Gothenburg, Sweden. She got her PhD in Chemical Sciences in 2004 at the University of Florence.

Research

The research interests of F. Baldelli Bombelli are focused on the development of engineered nanomaterials (ENM) for the diagnosis and treatment of untreatable diseases such as cancer and neurodegenerative pathologies. In particular, she has recently developed drug delivery systems and fluorinated nanomaterials that showed promising feature to be used as 19F-MRI contrast agents. Moreover, her research also aims at investigating the interactions between ENM and the cellular machinery to improve their efficiency in vivo and evaluate possible toxicity effects. Particularly, her work has been dedicated to the study of the protein corona complexes formed by nanomaterials in situ in relevant biological fluids.

Selected Publications

• Nanoparticles for ‘‘two color” 19F magnetic resonance imaging: Towards combined imaging of biodistribution and degradation. O. Koshkina et al. Journal of Colloid and Interface Science 2020, 565,278-287
• Multispectral MRI with Dual Fluorinated Probes toTrack Mononuclear Cell Activity in Mice. Chirizzi C. et al. Radiology 2019, 2, 351–357
• Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release. Maiolo D.et al., ACS Nano 2017, 11, 9413–9423
• The effect of the protein corona on the interaction between nanoparticles and lipid bilayers. Di Silvio D. et al., Journal of Colloid and Interface Science 2017, 504, 741-750
• High-resolution isolation of protein corona nanoparticles from complex physiological fluids. Di Silvio D. et al., Nanoscale, 2015,7, 11980-11990

For more information about Francesca Baldelli Bombelli present research projects, refer to the group website www.suprabionano.eu.

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