Emanuela Jacchetti obtained her Master’s degree in Physics from the University of Milan and completed her PhD in Physics, Astrophysics, and Applied Physics at the same institution. Throughout her career, she has worked at several prestigious research centers, including the Institute of Biophysics-CNR in Genoa and Pisa, the Advanced Biotechnology Centre in Genoa, the Scuola Normale Superiore in Pisa, and the Experimental Imaging Center at San Raffaele Hospital in Milan.
Since 2016, she has been affiliated with the Polytechnic University of Milan.
Her research integrates computational and experimental models to study tissue maturation processes, optimize pharmacological testing, and improve disease modeling. Her work spans multiple scientific fields, with the goal of advancing mechanobiology, bioengineering, and regenerative medicine through innovative biomedical approaches.
To achieve these objectives, she develops platforms for modeling complex biological systems, such as 3D microstructured scaffolds, Organ-on-Chip devices, Subcutaneous imaging windows.
These tools are integrated with high spatial-temporal resolution fluorescence microscopy, enabling precise analysis of cellular processes, tissue dynamics, and molecular interactions. Her platforms allow detailed investigation of cellular metabolism, oxygenation, and mechanotransduction in tissue maturation and disease progression.
Funded Projects
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2023–2027: HORIZON-MSCA-2021-DN-01 – Doctoral Network for a Shared Excellence of Fluorescent Lifetime Imaging Microscopy in Biomedical Applications (FLImagin3D). Co-PI
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2023–2025: PRIN2022 – Characterisation of the role of prometastatic MICAL2 on nuclear envelope and genome integrity through transcriptional control of Lamin A/C (VISION). PI
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2018–2021: MIUR-FARE – Direct laser writing nanofabricated imaging window for intravital evaluation of biomaterials (BEYOND). Co-PI
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2018–2019: Euro-BioImaging2018 – Effect of Nichoid substrates on mesenchymal stem cell migration and modulation of transcription factors nuclear import. PI
Selected Publications
1. Martinelli C, Bocconi A, Milone S, Baldissera T, Cherubin L, Buccioli G, Perottoni S, Conci C, Cerullo G, Osellame R, Chirico G, Jacchetti E*, Raimondi MT*. A 3D millifluidic model of a dermal perivascular microenvironment on a chip. Lab Chip. 2025 Jan 6. doi: 10.1039/d4lc00898g
2. Donnaloja F, Raimondi MT, Messa L, Barzaghini B, Carnevali F, Colombo E, Mazza D, Martinelli C, Boeri L, Rey F, Cereda C, Osellame R, Cerullo G, Carelli S, Soncini M*, Jacchetti E*. 3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells. APL Bioeng. 2023 Sep 7;7(3):036112. doi: 10.1063/5.0153215
3. Jacchetti E* and Nasehi R*, Boeri L, Parodi V, Negro A, Albani D, Osellame R, Cerullo G, Rodriguez Matas JF, Raimondi MT (2021). The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche. Scientific Reports 11:1-19 doi: 10.1038/s41598-021-81920-2
4. Raimondi MT, Donnaloja F, Barzaghini B, Bocconi A, Conci C, Parodi V, Jacchetti E* and Carelli S* (2020). Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19. Theranostics 10:7034-7052. doi:10.7150/thno.47406
5. Donnaloja F, Carnevali F, Jacchetti E* and Raimondi MT* (2020). Lamin A/C Mechanotransduction in Laminopathies. Cells 9:1306-1338, doi: 10.3390/cells9051306
