Published on the cover of the Journal «Macromolecules» (American Chemical Society) a study on the synthesis of a new generation of polymer-protein conjugates.

The results highlighted the potential of poly (glycerol monomethacrylate) as an alternative to polyethylene glycol (PEG) for extending the half-life of biotherapeutics. The proposed synthetic approach can inspire the design of a new class of conjugated proteins, through an optimal combination of macromolecular composition and topology.

Selective Protein Conjugation of Poly(glycerol monomethacrylate) and Poly(polyethylene glycol methacrylate) with Tunable Topology via Reductive Amination with Multifunctional ATRP Initiators for Activity Preservation

Filippo Moncalvo, Elisa Lacroce, Giulia Franzoni, Alessandra Altomare, Elisa Fasoli, Giancarlo Aldini, Alessandro Sacchetti, and Francesco Cellesi
«Macromolecules» 2022 55 (17), 7454-7468
DOI: 10.1021/acs.macromol.2c00783

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About the Cover:

Selective protein conjugation of polymers with tunable composition, molar mass, and topology for activity preservation and half-life extension.