Problem: Study of new techniques for the prescription of flow rate and mean pressure boundary conditions in
computational fluid-dynamics
Strategies: - Lagrange multipliers approach
- Control based approach (minimization of a suitable functional)
- Nitsche's method
Applications : haemodynamics
Video : Flow field in a human carotid - rigid domain - flow rate prescription with Lagrange multipliers Related publications :
Veneziani A., Vergara, Flow rate defective Boundary Conditions in Haemodynamics Simulations, Int. Journ. Num. Meth. Fluids, 47, pp. 803--816, 2005. pdf
Fernandez M., Moura A., Vergara C., Defective Boundary Conditions Applied to Multiscale Analysis of Blood Flow, ESAIM Proceedings & Surveys, CEMRACS 2004, 14, pp. 89-99, 2005. pdf
Moura A., Vergara C., Flow rate boundary conditions and multiscale modelling of the cardiovascular system in compliant domains, in Modelling in Medicine and Biology VI,
(eds. Ursino, Brebbia, Pontrelli, Magosso), pp. 351-359, related to Sixth International Conference on Modelling in Medicine and Biology, Bologna - September 7-9, 2005. pdf
Veneziani A., Vergara C., Flow Rate Boundary Conditions in Fluid-Dynamics, PAMM Proceedings in Applied Mathematics and Mechanics, 6,
pp. 35-38, 2006 (Proceedings of the GAMM meeting 2006, Berlin) pdf
Veneziani A., Vergara C.,
An approximate method for solving incompressible Navier-Stokes problem with flow rate conditions, Comp. Meth. Appl. Mech. Eng., 196 (9-12), pp. 1685-1700, 2007, pdf
Vergara C., Modellazione numerica di problemi con condizioni al contorno deficitarie in fluidodinamica incomprimibile,
Bollettino della Unione Matematica Italiana A, 10(2), pp. 371-374, 2007
Formaggia L., Veneziani A., Vergara C., A new approach to numerical solution of defective boundary value problems in incompressible fluid dynamics, SIAM J. Num. Anal., 46(6), pp. 2769-2794, 2008.
pdf
Formaggia L., Veneziani A., Vergara C., Flow rate boundary problems for an incompressible fluid in deformable domains: formulations and solution methods .
Comp. Meth. Appl. Mech. Eng., 199 (9-12), pp. 677-688, 2010.
pdf
Vergara C., Modular algorithms for the
numerical solution of the flow rate boundary value problem, Communications in Applied and Industrial
Mathematics, 1(1), pp. 237-257, 2010. pdf
Vergara C., Nitsche's method for
defective boundary value problems in incompressibile fluid-dynamics.
Journal of Scientific Computing , 46, pp. 100-123, 2011.
pdf
A. Porpora, P. Zunino, C. Vergara, M. Piccinelli, Numerical treatment of boundary conditions to replace lateral
branches in haemodynamics. Int. J. Numer. Meth. Biomed. Eng., 28(12), pp. 1165-1183, 2012.
pdf
L. Formaggia and C. Vergara, Prescription of general defective boundary
conditions in fluid-dynamics. Milan Journal of Mathematics, 80(2), pp. 333-350, 2012.
pdf
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications. Acta Numerica,
26, pp. 365-590, 2017 pdf
Formaggia L., Vergara C., Defective boundary conditions for PDEs with applications in haemodynamics.
In "Numerical Methods for PDEs", SEMA SIMAI Springer Series (D. Di Pietro, A. Ern, L. Formaggia eds.), 15, pp. 285-312, 2018.
pdf
Quarteroni A., Dede' L., Manzoni A., Vergara C., Mathematical Modelling of the Human Cardiovascular System -
Data, Numerical Approximation, Clinical Applications, Cambridge Monographs on Applied and Computational Mathematics, Cambridge University Press, 2019. pdf
Crugnola L., Vergara C. Inexact block LU preconditioners for incompressible fluids with flow rate conditions. arxiv, DOI:arXiv:2411.03929, 2024.
pdf
Parabolic profile - Unstable flow field (by . B. Guerciotti)
Lagrange multiplier - Stable flow field (by . B. Guerciotti)
2) Numerical solution of fluid-structure interaction problem (2006-onwards)
Problem: Study and analysis of new numerical techniques for the numerical solution of the problem
arising from the interaction between a fluid and a structure
Strategies: - Efficient partitioned methods of implicit type
- Stable and accurate partitioned methods of explicit type
- Quasi-Newton methods for monolithic solution
- Unfitted XFEM/DG and PolyDG approaches for an immersed thick structure and large displacements
Application : vascular and cardiac haemodynamics
Video : Flow field in a human carotid before the plaque removal Video : Flow field in a human carotid after the plaque removal Related publications :
Nobile F., Vergara C., An effective fluid-structure interaction formulation for vascular dynamics by generalized Robin conditions, SIAM J. Sc. Comp., 30(2), pp. 731-763, 2008 pdf
Badia S., Nobile F., Vergara C., Fluid-structure partitioned procedures based on Robin transmission conditions,
J. Comp. Phys., 227, pp. 7027-7051, 2008. pdf
Badia S., Nobile F., Vergara C., Robin-Robin preconditioned Krylov methods
for fluid-structure interaction problems . Comp. Meth. Appl. Mech. Eng., 198 (33-36), pp. 2768-2784, 2009.
pdf
Formaggia L., Veneziani A., Vergara C., Flow rate boundary problems for an incompressible fluid in deformable domains: formulations and solution methods .
Comp. Meth. Appl. Mech. Eng., 199 (9-12), pp. 677-688, 2010.
pdf
Gerardo-Giorda L., Nobile F., Vergara C.,
Analysis and optimization of Robin-Robin partitioned procedures in fluid-structure interaction problems.
SIAM J. Num. Anal. , 48(6), pp. 2091-2116, 2010. pdf
F. Nobile, C. Vergara, Partitioned algorithms for fluid-structure interaction problems in haemodynamics. Milan Journal of Mathematics, 80(2), pp. 443-467, 2012. pdf
Pozzoli M., Vergara C., Nobile F. Efficient algorithms for the solution of fluid-structure interaction problems in haemodynamic applications, Proceedings of the Conference "Numerical Methods for Hyperbolic Equations: Theory and Applications", Santiago de Compostela, pp. 355-364, 2013. pdf
F. Nobile, M. Pozzoli, C. Vergara, Time accurate partitioned algorithms for the solution of fluid-structure interaction problems
in haemodynamics. Computer and Fluids, 86, pp. 470-482, 2013. pdf
F. Nobile, M. Pozzoli, C. Vergara, Inexact accurate partitioned algorithms for fluid-structureinteraction problems with finite elasticity in haemodynamics. Journal of Computational Physics. DOI:10.1016/j.jcp.2014.05.020. pdf
Gigante G., Vergara C., Analysis and optimization of the generalized Schwarz method for elliptic
problems with application to fluid-structure interaction.
Numer. Math., 131(2), pp. 369--404, 2015.
pdf
G. Gigante, C. Vergara, Optimized Schwarz method for the fluid-structure interaction with cylindrical interfaces.
Domain Decomposition Methods in Science and Engineering XXII - Lecture Notes in Computational Science and Engineering - Proceedings of the 22nd International Conference on Domain Decomposition Methods, 104, pp. 521-529, 2016.
pdf
Zonca S., Vergara C., Formaggia L., An unfitted formulation for the interaction of an incompressible fluid with a thick structure via an XFEM/DG approach.
SIAM J. Sc. Comp., 40(1), pp. B59-B84, 2018 pdf
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications. Acta Numerica,
26, pp. 365-590, 2017 pdf
Quarteroni A., Vergara C.,
Computational models for hemodynamics. Encyclopedia of Continuum Mechanics. doi:10.1007/978-3-662-53605-6_35-1, 2018. pdf
Antonietti P., Verani M., Vergara C., Zonca S., Numerical solution of fluid-structure interaction problems by means of a high order Discontinuous Galerkin method on polygonal grids. Finite Elements in Analysis and Design, 159, pp. 1-14, 2019. pdf
Vergara C., Zonca S., Extended Finite Elements method for fluid-structure interaction with an immersed thick non-linear structure. In "Mathematical and Numerical Modeling of the Cardiovascular System and Applications", SEMA SIMAI Springer Series (D. Boffi, L. Pavarino, G. Rozza, S. Scacchi, C. Vergara eds.), pp. 209-243, 2018. pdf
Quarteroni A., Dede' L., Manzoni A., Vergara C., Mathematical Modelling of the Human Cardiovascular System -
Data, Numerical Approximation, Clinical Applications, Cambridge Monographs on Applied and Computational Mathematics, Cambridge University Press, 2019. pdf
Gigante G., Vergara C., On the stability of a loosely-coupled scheme based on a Robin interface condition for fluid-structure interaction. Computers and Mathematics with Applications, 96, pp. 109-119, 2021. pdf
Gigante G., Sambataro G., Vergara C., Optimized Schwarz methods for spherical interfaces with application to fluid-structure interaction. SIAM J. Sc. Comp., 42(2), A751-A770, 2020. pdf
Zonca S., Antonietti P.F., Vergara C. A Polygonal Discontinuous Galerkin formulation for contact mechanics in fluid-structure interaction problems. Comm. Comp. Phys., 30, pp. 1-33, 2021. pdf
Gigante G., Vergara C., On the choice of interface parameters in Robin-Robin loosely coupled schemes for fluid-structure interaction. Fluids, 6(6), pp. 213-231, 2021. pdf
Bucelli M., Dede' L., Quarteroni A., Vergara C., Partitioned and monolithic algorithms for the numerical solution
of cardiac fluid-structure interaction. Comm. Comp. Phys. 32(5), 1217-1256, 2023.
pdf
Bucelli M., Geraint Gabriel M., Quarteroni A., Gigante G., Vergara C.,
A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction. Journal of Computational Physics, 490, 112326, 2023. pdf
Fumagalli I., Vergara C., Novel approaches for the numerical solution of fluid-structure interaction in the aorta. Biomechanics of the Aorta - Modeling for Patient Care, Chapter 16, Edited by: T. Christian Gasser, Stephane Avril and John A. Elefteriades, Academic Press, 2024.
pdf
Velocity streamlines and wall displacements vectors at systole - carotid geometry (by. M. Pozzoli)
3) Geometrical multiscale modeling of the cardiovascular system (2003-onwards)
Problem: Study of coupling techniques among heterogeneous models to describe the cardiovascular system
Strategies: Three dimensional/one dimensional coupling based on the total pressure
Application : Haemodynamics
Related publications :
Balossino R., Migliavacca F., Pennati G., Dubini G., Vergara C., Formaggia L., Venenziani A., Multiscale Models of the Cardiovascular System Applied to the Study of the Flow in a Carotid Bifurcation,
in Technological innovation and evaluation of medical devices for the cardiovascular system, Rapporti Istisan, 05/46, 2004.
Veneziani A., Vergara, Flow rate defective Boundary Conditions in Haemodynamics Simulations, Int. Journ. Num. Meth. Fluids, 47, pp. 803--816, 2005. pdf
L. Formaggia, A. Quarteroni, C. Vergara, On the physical consistency between three-dimensional and one-dimensional models in haemodynamics.
Journal of Computational Physics. DOI:10.1016/j.jcp.2012.08.001. pdf
Quarteroni A., Veneziani A., Vergara C., Geometric multiscale modeling of the cardiovascular system, between theory and practice. Comp. Meth. Appl. Mech. Eng., 302, pp. 193--252, 2016. pdf
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications. Acta Numerica,
26, pp. 365-590, 2017 pdf
Quarteroni A., Dede' L., Manzoni A., Vergara C., Mathematical Modelling of the Human Cardiovascular System -
Data, Numerical Approximation, Clinical Applications, Cambridge Monographs on Applied and Computational Mathematics, Cambridge University Press, 2019. pdf
Dede' L., Regazzoni F., Vergara C., Zunino P., Guglielmo M., Scrofani R., Fusini L., Cogliati C., Pontone G., Quarteroni A. Modeling the cardiac response to hemodynamic changes associated with COVID-19: a computational study. Mathematical Biosciences and Engineering, 18(4), pp. 3364-3383, 2021. pdf
Piersanti R., Regazzoni F., Salvador M., Corno A.F., Dede' L., Vergara C., Quarteroni A.,
3D-0D closed-loop model for the simulation of cardiac biventricular electromechanics.
Comp. Meth. Appl. Mech. Eng., 391, 114607, 2022. pdf
Marcinno' F., Zingaro A., Fumagalli I., Dede' L., Vergara C., A computational study of blood flow dynamics in the pulmonary arteries.
Vietnam Journal of Mathematics, 51, 127-149, 2023.
pdf
Ruffino L., Santoro A., Sparvieri, S., Regazzoni, F. Adebo D.A., Quarteroni A., Vergara C., Corno A.F.,
Computational analysis of cardiovascular effects of COVID- 19 infection in children. J Pediatric Adv Research, 2023.
pdf
Tonini A., Vergara C., Regazzoni F., Dede' L., Scrofani R., Cogliati C., Quarteroni A., A mathematical model to assess the effects of COVID-19 on the cardiocirculatory system. Scientific Reports - Nature, 14, 8304, 2024. pdf
Tonini A., Regazzoni F., Salvador M., Dede' L., Scrofani R., Fusini L., Cogliati C., Pontone G., Vergara C., Quarteroni A.,
Two new calibration techniques of lumped-parameter mathematical models for the cardiovascular system. Int. J. Num. Meth. Eng., 126(1), e7648, 2025. pdf
Criseo E., Fumagalli I., Quarteroni A., Marianeschi S.M., Vergara C., Computational haemodynamics for pulmonary valve replacement by means of a reduced Fluid-Structure Interaction model. Int. J. Num. Meth. Biomed. Eng., 40(9), e3846, 2024. pdf
3D-0D coupling between circulatory system and electro-mechanical model (figure by Piersanti/Regazzoni)
Viscardi F., Vergara C., Antiga L., Merelli S., Veneziani A., Puppini G., Faggian G., Mazzucco A., Luciani G.B.,
Comparative finite-element model analysis of ascending
aortic flow in bicuspid and tricuspid aortic valve.
Artificial Organs., 34(12), pp. 1114-1120, 2010. pdf
Luciani G.B., Antiga L., Puppini G., Viscardi F., Faggian G., Mazzucco A., Vergara C.,Commissure Orientation Influences Aortic Aneurysm Morphology in Normally Functioning Bicuspid Aortic Valves: A Parametric, Computational Fluid Dynamic Study. Circulation. In: Abstracts From Scientific Sessions 2011. Orlando, USA, 13-15.11.2011, vol. 124(21 S). pdf
Vergara C., Viscardi F., Antiga L., Luciani G.B.,
Influence of bicuspid valve geometry on ascending aortic fluid-dynamics: a parametric study.
Artificial Organs , 36(4), pp 368-378, 2012. pdf
E. Faggiano, L. Antiga, G. Puppini, A. Quarteroni, G.B. Luciani, C. Vergara, Helical Flows and Asymmetry of Blood Jet in Dilated
Ascending Aorta with Normally Functioning Bicuspid Valve.Biomechanics and Modeling in Mechanobiology, 12(4), pp. 801-813, 2013. pdf
Bonomi D., Vergara C., Faggiano E., Stevanella M., Conti C.,
Redaelli A., Puppini G., Faggian G., Formaggia L., Luciani G.B., Influence of the aortic valve leaflets on the
fluid-dynamics in aorta in presence of a normally
functioning bicuspid valve. Biomechanics and Modeling in Mechanobiology, 14(6), pp.1349--1361, 2015.
pdf
Kara R., Vergara C., Assessing Turbulent Effects in Ascending Aorta in Presence of Bicuspid Aortic Valve. Computer Methods in Biomechanics and Biomedical Engineering, 27, 2349-2361, 2023. pdf
Flow exiting from the left ventricle. Left: radiological image; Middle: BAV simulation; Right: Tricuspid configuration
b) Hemodynamics in the ascending and thoracic aorta for TAVI and TEVAR Problems :
- Study of influence of hemodynamics on TAVI degeneration
- Study of blood forces in thoracic aortic aneurysms
Clinical partner : Centro Cardiologico Monzino, Milan, Italy;
Divisions of Vascular-surgery and Radiology, Fondazione Ca' Granda - Policlinico di Milano, Italy
Related publications :
Fumagalli I., Polidori R., Renzi F., Fusini L., Quarteroni A., Pontone G., Vergara C., Fluid-structure interaction analysis of transcatheter aortic valve implantation. Int. J. Num. Meth. Biomed. Eng., 39(6), e3704, 2023. pdf
Crugnola L., Vergara C., Fusini L., Fumagalli I., Luraghi G., Redaelli A., Pontone G., Computational hemodynamic indices to identify Transcatheter Aortic Valve Implantation degeneration. Computer Methods and Programs in Biomedicine, 259, 108517, 2024. pdf
Duca F., Bissacco D., Crugnola L., Faitini C., Domanin M., Migliavacca F. Trimarchi S., Vergara C., Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms. The Jouranl of Physiology, To appear. DOI: 10.1113/JP287278. pdf
Blood dynamics in ascending aorta in presence of TAVI with endograft (by L. Crugnola)
c) Haemodynamics in the abdominal aorta in presence of an aneurysm Problems :
- Study of the correlation between lumen displacement (from 4D-CT images) and
haemodynamic forces
- Study of the transition to turbulence effects
- Blood dynamics in presence of endograft
Clinical partner : Divisions of Vascular-surgery and Radiology, Fondazione Ca' Granda - Policlinico di Milano, Italy
Related publications :
M. Piccinelli, C. Vergara, L. Antiga, L. Forzenigo, P. Biondetti, M. Domanin,
Impact of hemodynamics on lumen boundary displacements
in abdominal aortic aneurysms by means of dynamic
computed tomography and computational fluid dynamics.
Biomechanics and Modeling in Mechanobiology, 12(6), pp. 1263-1276, 2013.
pdf
Vergara C., Le Van D., Quadrio M., Formaggia L., Domanin M.,
Large Eddy Simulations of blood dynamics in abdominal aortic aneurysms. Medical Engineering & Physics , 47, pp. 38-46, 2017 pdf
Domanin M., Piazzoli G., Trimarchi S., Vergara C., Image-based displacements analysis and com-
putational blood dynamics after endovascular aneurysm repair. Annals of Vascular Surgery, 69, pp. 400-412, 2020. pdf
Blood dynamics in AAA with endograft (by G. Piazzoli)
d) Haemodynamics in atherosclerotic carotids Problem :
- Study the effect of the plaque removal (Endarterectomy)
on the fluid-dynamics
- Study of the transition to turbulence effects
- Modeling plaque progression
Clinical partner : Divisions of Vascular-surgery and Radiology, Fondazione Ca' Granda - Policlinico di Milano, Italy
Related publications :
Guerciotti B., Vergara C., Azzimonti L., Forzenigo L., Buora A., Biondetti P., Domanin M., Computational study of the
fluid-dynamics in carotids before and after endarterectomy. Journal of
Biomechanics, 49(1), pp. 26--38, 2016. pdf
Lancellotti R.M.. Vergara C., Valdettaro L., Bose S., Quarteroni A.,
Large Eddy Simulations for blood fluid-dynamics in real stenotic carotids. Int. J. Numer. Meth. Biomed. Eng., 33(11), e2868, 2017
pdf
Domanin M., Buora A., Scardulla F., Guerciotti B., Forzenigo L., Biondetti P., Vergara C., Computational fluid-dynamic analysis of carotid bifurcations after endarterectomy: closure with patch graft versus direct suture. Annals of Vascular Surgery , 44, pp. 325 335, 2017. pdf
Guerciotti B., Vergara C.,
Computational comparison between Newtonian and non-Newtonian blood rheologies in stenotic vessels.
In "Biomedical Technology", Lecture Notes in Applied
and Computational Mechanics 84 (P. Wriggers and T. Lenarz eds.), Springer, pp. 169-183, 2018.
pdf
Domanin M., Vergara C., Regarding "closure technique after carotid endarterectomy influences local hemodynamics",
Journal of Vascular Surgery, 63(5), p. 1409, 2016 pdf
Domanin M., Bissacco D., Le Van D., Vergara C.,
Computational fluid-dynamic comparison between patch-based and direct suture closure techniques after carotid endarterectomy. Journal of Vascular Surgery, 67(3), pp. 887-897, 2018.
pdf
Domanin M., Gallo D., Vergara C., Biondetti P., Forzenigo L.V., Morbiducci U., Prediction of
long term restenosis risk after surgery in the carotid bifurcation by hemodynamic and geometric
analysis. Annals of Biomedical Engineering, 47(4), pp. 1129-1140, 2019. pdf
Pozzi S., Vergara C., Mathematical and numerical models of atherosclerotic plaque progression in carotid arteries. In ''Numerical Mathematics and Advanced Applications ENUMATH 2019'' - Lecture Notes in Computational Science and Engineering, 139, 2021. pdf
Pozzi S., Domanin M., Forzenigo L., Votta E., Zunino P., Redaelli A., Vergara C., A surrogate model for plaque modeling in carotids based on Robin conditions calibrated by cine MRI data . Int. J. Num. Meth. Biomed. Eng., 37(5), e3447, 2021. pdf
Morbiducci U., Mazzi V., Domanin M., De Nisco G., Vergara C., Steinman D.A., Gallo D. Wall shear stress topological skeleton independently predicts long-term restenosis after carotid bifurcation endarterectomy. Annals of Biomedical Engineering, 48, pp. 2936 2949, 2020.
pdf
Pozzi S., Redaelli A., Vergara C., Votta E., Zunino P., Mathematical and numerical modeling of atherosclerotic plaque progression based on fluid-structure interaction.
Journal of Mathematical Fluid Mechanics, 23, 74, 2021. pdf
Bennati L., Vergara C., Domanin M., Malloggi C., Bissacco D., Trimarchi S., Silani V., Parati G., Casana R., A computational fluid structure interaction study for carotids with different atherosclerotic plaques. Journal of Biomechanical Engineering, 143(9),
091002, 2021. pdf
Domanin M., Bennati L., Vergara C., Bissacco D., Malloggi C., Silani V., Parati G., Trimarchi S., Casana R.,
Fluid structure interaction analysis to stratify the behavior of different atheromatous carotid plaques.
The Journal of Cardiovascular Surgery, 64(1), 58-56, 2023.
pdf
Vorticity before and after the plaque removal (by B. Guerciotti)
e) Hemodynamics in arteriovenous fistolae for hemodialsys Problem : Study the influence of the angle of anastomosis on the fluid-dynamic performance
Clinical partner : EOC-Ente Ospedaliero Cantonale,
Lugano 6900, Switzerland.
Related publications :
Stella S., Vergara C., Giovannacci L., Quarteroni A., Prouse G., Assessing the disturbed flow and the transition to turbulence in the arteriovenous fistula. . Journal of Biomechanical Engineering , 141(10), 101010, 2019. pdf
Prouse G., Stella S., Vergara C., Quarteroni A., Engelberger S., Canevascini R., Giovannacci L., Computational Analysis of Turbulent Hemodynamics in Radiocephalic Arteriovenous Fistulas to Determine the Best Anastomotic Angles. Annals of Vascular Surgery, 68, pp. 451 459, 2020. pdf
Marcinno' F., Vergara C., Giovannacci L., Quarteroni A., Prouse G., Computational fluid-structure interaction analysis of the end-to-side radio-cephalic arteriovenous fistula. Comp. Meth. & Progr. Biomed., 249, 108146, 2024. pdf
Blood dynamics in arteriovenous fistolae with different angle of anastomosis (by S. Stella)
f) Fluid-dynamics in coronaries, coronary by-passes, and cardiac perfusion Problems :
- Study the relation between risk of restenosis in simple and multiple by-passes
- Assess the influence of guide-wire in FFR estimates
- Estimate cardiac blood flow maps
Clinical partners :
- Divisions of Cardio-surgery and Radiology, Ospedale Sacco, Milan, Italy
- Division of Cardiology and Cardiac Imaging, Centro Cardiologico Monzino, Milan, Italy
Related publications :
Guerciotti B., Vergara C., Ippolito S., Quarteroni A., Antona C., Scrofani R.,
Computational study of the risk of restenosis in coronary bypasses. Biomechanics and Modeling in Mechanobiology. 16(1), pp. 313-332, 2017. pdf
Guerciotti B., Vergara C., Ippolito S., Quarteroni A., Antona C., Scrofani R.,
A computational fluid-structure interaction analysis of coronary Y-grafts. Medical Engineering & Physics , 47, 117-127, 2017 pdf
Guerciotti B., Vergara C.,
Computational comparison between Newtonian and non-Newtonian blood rheologies in stenotic vessels.
In "Biomedical Technology", Lecture Notes in Applied
and Computational Mechanics 84 (P. Wriggers and T. Lenarz eds.). DOI:10.1007/978-3-319-59548-1_10, 2017.
pdf
Di Gregorio* S., Vergara* C., Montino Pelagi G., Baggiano A., Zunino P., Guglielmo M., Fusini L., Muscogiuri G., Rossi A., Rabbat M.G., Quarteroni A., Pontone G., Prediction of myocardial blood flow under stress conditions by means of a computational model.
European Journal of Nuclear Medicine and Molecular Imaging. , 49:1894 1905, 2022.
*These authors equally contributed to the work. pdf
Lucca A., Fraccarollo L., Fossan F.E., Braten A.T., Pozzi S., Vergara C., Muller L.O., Impact of pressure guidewire on model-based FFR prediction.
Cardiovascular Engineering and Technology, 15, 251-263, 2024. pdf
Montino Pelagi G., Baggiano A., Regazzoni F., Fusini L., Ali' M., Pontone G., Valbusa G., Vergara C., Personalized pressure conditions and calibration for a predictive computational model of coronary and myocardial blood flow. Annals Biomed. Eng., 52, 1297-1312, 2024. pdf
Criseo E., Baggiano A., Montino Pelagi G., Nannini G., Redaelli A., Pontone G., Vergara C., Development of a digital twin for the diagnosis of cardiac perfusion defects, medRXiv, DOI:10.1101/2025.02.04.25321638, 2024. pdf
Fluid and structure meshes of a muyltiple coronary by-pass (left). Streamlines of blood dynamics (right) (by B. Guerciotti)
g) Cardiac blood pumps Problem : Study the blood dynamics in presence of cardiac blood pumps
Related publications :
Scardulla S., Pasta S., D'Acquisto L., Sciacca S., Agnese V., Vergara C., Quarteroni A., Clemenza F., Bellavia D., Pilato M.,
Shear Stress Alterations in the Celiac Trunk of Patients with Continuous-Flow Left Ventricular Assist Device by In-Silico and In-Vitro Flow Analysis.
Journal of Heart and Lung Transplantation, 36(8), pp. 906-913, 2017. pdf
Martinolli M., Biasetti J.,Zonca S., Polverelli L., Vergara C., Extended Finite Element Method for Fluid-Structure Interaction in Wave Membrane Blood Pumps.
Int. J. Num. Meth. Biomed. Eng., 37(7), e3467, 2021. pdf
Martinolli M., Cornat F., Vergara C.,
Computational Fluid-Structure Interaction Study of a new Wave Membrane Blood Pump.
Cardiovascular Engineering and Technology, 13, 373 392, 2022. pdf
Blood dynamics in a wave membrane blood pump (by M. Martinolli)
h) Cardiac blood dynamics for the study of valve diseases Problems :
- Image-based atrial and ventricular CFD in moving domains with immersed valves
- Systolic anterior motion and obstruction in hypertrophic cardiomyopathy
- Mitral regurgitation
Clinical partners :
- Divisions of Cardio-surgery and Radiology, Ospedale Sacco, Milan, Italy
- Divisions of Cardio-surgery and Radiology, Ospedale Borgo Trento, Verona, Italy
Related publications :
Nestola M.G.C., Faggiano E., Vergara C., Lancellotti R.M., Ippolito S., Filippi S., Quarteroni A.,
Scrofani R., Computational comparison of aortic root stresses in presence of stentless and stented
aortic valve bio-prostheses. Computer Methods in Biomechanics and Biomedical Engineering, 20(2), pp. 171-181, 2017.
pdf
Fumagalli I., Fedele M., Vergara C., Dede' L., Ippolito S., Nicolo' F., Antona C., Scrofani R., Quarteroni A.,
An Image-based Computational Hemodynamics Study of the Systolic Anterior Motion of the Mitral Valve.
Computers in Biology and Medicine, 123, 103922, 2020.
pdf
Fumagalli I., Vitullo P., Vergara C., Fedele M., Corno A.F., Ippolito S., Scrofani R., Quarteroni A.,
Image-based computational hemodynamics analysis of
systolic obstruction in hypertrophic cardiomyopathy.
Frontiers in Physiology - Computational Physiology and Medicine, 12, 787082, 2022. pdf
Bennati L., Vergara C., Giambruno V., Fumagalli I., Corno A.F., Quarteroni A., Puppini G., Luciani G.B., An image-based computational fluid dynamics study of mitral regurgitation in presence of prolapse. Cardiovascular Engineering and Technology, 14, 457-475, 2023. pdf
Bennati L., Giambruno V., Renzi F., Di Nicola V., Maffeis C., Puppini G., Luciani G.B., Vergara C., Turbulence and blood washout in presence of mitral regurgitation: a computational fluid-dynamics study in the complete left heart. Biomech. Model. Mechanobiol., 22, 1829-1846, 2023. pdf
Bennati L., Puppini G., Giambruno V., Luciani G.B., Vergara C., Image-Based Computational Fluid Dynamics to Compare Two Repair Techniques for Mitral Valve Prolapse. Annals Biomed. Eng., 52, 3295-3311, 2024. pdf
Renzi F., Puppini G., Luciani G.B., Vergara C. Image-based computational hemodynamics in the right heart. Biomech. Model. Mechanobiol. To appear.
pdf
Renzi F., Bennati L., Fedele M., Giambruno V., Quarteroni A., Puppini G., Luciani G.B., Vergara C., From cine-MRI to computational models of blood flow within the heart. Vascular Pharmacology, 155, 107343, 2024. pdf
Atrial and ventricular blood dynamics in presence of mitral regurgitation (by L. Bennati)
i) Other publications:
Corno A., Vergara C., Subramanian C., Johnson R.A., Passerini T., Veneziani A., Formaggia L., Alphonso N., Quarteroni A., Jarvis J.C., Assisted Fontan procedure: animal and in vitro models and
computational fluid dynamics study , Interactive CardioVascular and Thoracic Surgery, 10, pp. 679-684, 2010 pdf
Dubini G. et al.,
Trends in biomedical engineering: focus on Patient Specific Modeling and Life Support Systems.
J. Appl. Biomater. Biomech., 9(2), pp. 109 - 117, 2011. pdf
Arimon A., Balossino R., D'Angelo C., Doorly D., Dubini G., Fernandez M., Gerbeau J.F.,
Giordana S., Migliavacca F., Pennati G., Peiro' J., Prosi M., Sherwin S., Vergara C., Vidrascu M., Zunino P.,
Applications and test cases, in Cardiovascular Mathematics, Formaggia L., Quarteroni A., Veneziani A. eds., Springer, 2009.
Link
Tuveri M., Milani E., Marchegiani G., Landoni L., Torresani E., Capelli P., Sperandio N., D'onofrio M., Salvia R.. Vergara C., Bassi C., Hemodynamics and remodeling of the portal confluence in patients with cancer of the pancreatic head: a pilot study. Langenbeck's Archives of Surgery , 407, 143-152, 2022. pdf
Tonini A., Vergara C., Regazzoni F., Dede' L., Scrofani R., Cogliati C., Quarteroni A., A mathematical model to assess the effects of COVID-19 on the cardiocirculatory system. Scientific Reports - Nature, 14, 8304, 2024. pdf
Criseo E., Fumagalli I., Quarteroni A., Marianeschi S.M., Vergara C., Computational haemodynamics for pulmonary valve replacement by means of a reduced Fluid-Structure Interaction model. Int. J. Num. Meth. Biomed. Eng., 40(9), e3846, 2024. pdf
Capuano E., Regazzoni F., Maines M., Fornara S., Locatelli V., Catanzariti D., Stella S., Nobile F., Del Greco M., Vergara C., Personalized Computational Electro-mechanics Simulations to Optimize Cardiac Resynchronization Therapy. Biomech. Model. Mechanobiol., 23, 1977-2004, 2024. pdf
Fumagalli I., Pagani S., Vergara C., Dede' L., Adebo D.A., Del Greco M., Frontera A., Luciani G.B., Pontone G., Scrofani R., Quarteroni A., The role of computational methods in cardiovascular medicine: a narrative review. Traslational Pediatrics, 13(1), 146-163, 2024. pdf
WSS in the portal vein and corresponding histological tumor analysis (by E. Milani)
Problem: Provide convergence analyses and optimization of the generalized Schwarz method for specific interfaces
Cases: Fluid-structure interaction problem, cylindrical interfaces, geometric heterogeneous coupling
Related publications :
L. Gerardo-Giorda, F. Nobile, C. Vergara, Analysis and optimization of Robin-Robin partitioned procedures in fluid-structure interaction problems.
SIAM J. Num. Anal. , 48(6), pp. 2091-2116, 2010. pdf
G. Gigante, M. Pozzoli, C. Vergara, Optimized Schwarz Methods for the diffusion-reaction problem with cylindrical interfaces .
SIAM J. Num. Anal. , 51(6), pp. 3402-3420, 2013. pdf
Gigante G., Vergara C., Analysis and optimization of the generalized Schwarz method for elliptic
problems with application to fluid-structure interaction.
Numer. Math., 131(2), pp. 369--404, 2015.
pdf
G. Gigante, C. Vergara, Optimized Schwarz method for the fluid-structure interaction with cylindrical interfaces.
Domain Decomposition Methods in Science and Engineering XXII - Lecture Notes in Computational Science and Engineering - Proceedings of the 22nd International Conference on Domain Decomposition Methods, 104, pp. 521-529, 2016.
pdf
Gigante G., Vergara C., Optimized Schwarz methods for the coupling of cylindrical geometries along the axial direction. Mathematical Modelling and Numerical Analysis (M2AN),
52, pp.1597-1615, 2018. pdf
Gigante G., Sambataro G., Vergara C., Optimized Schwarz methods for spherical interfaces with application to fluid-structure interaction. SIAM J. Sc. Comp., 42(2), A751-A770, 2020. pdf
Bucelli M., Geraint Gabriel M., Quarteroni A., Gigante G., Vergara C.,
A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction. Journal of Computational Physics, 490, 112326, 2023. pdf
Convergence set (in blue) of interface parameters for a general elliptic problem
6) Modeling the cardiac function - Electrophysiology & Electro-Mechanics (2012-onwards)
Problems: - Generation of a patient-specific Purkinje network in computational cardiology
- Modeling the electro-mechanical activity in the myocardium
- Study of Cardiac Resynchronization Therapy and arrhytmogenesis due to ischemia
Clinical data: In-vivo measurements of the electrical activity
Related publications :
Vergara C., Palamara S., Catanzariti D., Pangrazzi C., Nobile F., Centonze M.,Faggiano E., Maines M., Quarteroni A., Vergara G., Patient-specific generation of the Purkinje network driven by clinical measurements of a normal propagation. Medical & Biological Engineering & Computing,
52(10), pp. 813--826, 2014. pdf
Palamara S., Vergara C., Catanzariti D., Faggiano E., Centonze M., Pangrazzi C., Maines M., Quarteroni A., Computational generation of the Purkinje network driven by clinical measurements: The case of pathological propagations. Int. J. Num. Meth. Biomed. Eng., 30(12), pp. 1558--1577, 2014. pdf
Palamara S., Vergara C., Faggiano E., Nobile F., An effective algorithm for the generation of patient-specific Purkinje networks in computational electrocardiology. J. Comp. Phys., 283, pp. 495--517, 2015.
pdf
Lange M., Palamara S., Lassila T.,
Vergara C., Quarteroni A., Frangi A.F., Efficient Numerical Schemes for Computing
Cardiac Electrical Activation over Realistic
Purkinje Networks: Method and Verification, in "Functional Imaging and Modeling of the Heart", Proceedings of the 8th International Conference, FIMH 2015, Springer, pp. 430-438, 2015. pdf
Vergara C., Lange M., Palamara S., Lassila T., Frangi A.F., Quarteroni A.,
A coupled 3D-1D numerical monodomain solver for cardiac electrical activation in the myocardium with detailed Purkinje network.
Journal of Computational Physics, 308, pp. 218--238, 2016. pdf
Lange M., Palamara S., Lassila T., Vergara C., Quarteroni A., Frangi A.F.,
Improved hybrid/GPU algorithm for solving cardiac electrophysiology problems on Purkinje networks..
Int. J. Numer. Meth. Biomed. Eng., 33(6), e2835, 2017. pdf
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications. Acta Numerica,
26, pp. 365-590, 2017 pdf
Quarteroni A., Vergara C.,
Computational models for hemodynamics. Encyclopedia of Continuum Mechanics. doi:10.1007/978-3-662-53605-6_35-1, 2018. pdf
Landajuela M., Vergara C., Gerbi A., Dede' L., Formaggia L., Quarteroni A., Numerical approximation of the electromechanical coupling in the left ventricle with inclusion of the Purkinje network.
Int. J. Num. Meth. Biomed. Eng., 34, e2984, 2018. pdf
Quarteroni A., Vergara C., Landajuela M., Mathematical and Numerical Description of the Heart Function. In ''Imagine Math 6'' (M. Emmer and M. Abate eds.), Springer, pp. 171-177, 2018.
pdf
Quarteroni A., Dede' L., Manzoni A., Vergara C., Mathematical Modelling of the Human Cardiovascular System -
Data, Numerical Approximation, Clinical Applications, Cambridge Monographs on Applied and Computational Mathematics, Cambridge University Press, 2019. pdf
Stella S., Vergara C., Maines M., Catanzariti D., Africa P., Dematte' C., Centonze M., Nobile F., Del Greco M., Quarteroni A. Integration of activation maps of epicardial veins in computational cardiac
electrophysiology . Computers in Biology and Medicine, 127, 104047, 2020.
pdf
Piersanti R., Africa P.C., Fedele M., Vergara C., Dede' L., Corno A.F., Quarteroni A. Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations. Comp. Meth. Appl. Mech. Eng., 373, 113468, 2021.
pdf
Vergara C., Stella S., Maines M., Africa P.C., Catanzariti D., Dematte' C., Centonze M., Nobile F., Quarteroni A., Del Greco M.,
Computational electrophysiology of the coronary sinus branches based on electroanatomical mapping for the prediction of the latest
activated region. Medical & Biological Engineering & Computing. 60, 2307 2319, 2022.
pdf
Piersanti R., Regazzoni F., Salvador M., Corno A.F., Dede' L., Vergara C., Quarteroni A.,
3D-0D closed-loop model for the simulation of cardiac biventricular electromechanics.
Comp. Meth. Appl. Mech. Eng., 391, 114607, 2022. pdf
Stella S., Regazzoni F., Vergara C., Dede' L., Quarteroni A.,
A fast cardiac electromechanics model coupling the Eikonal and the nonlinear mechanics equations.
Mathematical Models and Methods in Applied Sciences (M3AS), 32(8), 1531--1556, 2022.
pdf
Quarteroni A., Dede' L., Regazzoni F., Vergara C., A mathematical model of the human heart suitable to address clinical problems.
Japan Journal of Industrial and Applied Mathematics, 40, 1547-1567, 2023. pdf
Botta F., Calafa' M., Africa P.C., Vergara C., Antonietti P.F., High-order Discontinuous Galerkin Methods for the Monodomain and Bidomain Models.
Mathematics in Engineering, 6(6), 726-741, 2024. pdf
Capuano E., Regazzoni F., Maines M., Fornara S., Locatelli V., Catanzariti D., Stella S., Nobile F., Del Greco M., Vergara C., Personalized Computational Electro-mechanics Simulations to Optimize Cardiac Resynchronization Therapy. Biomech. Model. Mechanobiol., 23, 1977-2004, 2024. pdf
Corda A., Pagani S., Vergara C., Influence of acute myocardial ischemia on arrhythmogenesis: a computational study, medRXiv, DOI:10.1101/2024.11.20.24317476, 2024. pdf
Brunati S., Bucelli M., Piersanti R., Dede' L., Vergara C. Coupled Eikonal problems to model cardiac reentries in Purkinje network and myocardium. arxiv, DOI: arXiv:2412.13837, 2024.
pdf
Electro-anatomical mapping (Cardiology Division, Ospedale S. Maria del Carmine,
Rovereto (TN), Italy) Arrhythmia induced by acute ischemia (by A. Corda)
7) Modeling the cardiac function - Hemodynamics & Perfusion (2018-onwards)
Problems: - Multiscale modeling of the cardiac perfusion
- Image-based ventricular and atrial blood dynamics
Clinical data: Dynamic atrial and ventricular images
Related publications :
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications. Acta Numerica,
26, pp. 365-590, 2017 pdf
Quarteroni A., Vergara C.,
Computational models for hemodynamics. Encyclopedia of Continuum Mechanics. doi:10.1007/978-3-662-53605-6_35-1, 2018. pdf
Quarteroni A., Dede' L., Manzoni A., Vergara C., Mathematical Modelling of the Human Cardiovascular System -
Data, Numerical Approximation, Clinical Applications, Cambridge Monographs on Applied and Computational Mathematics, Cambridge University Press, 2019. pdf
Di Gregorio S., Fedele M., Pontone G., Corno A.F., Zunino P., Vergara C., Quarteroni A., A computational model applied to myocardial perfusion in the human heart: From large coronaries to microvasculature. Journal of Computational Physics, 424, 109836, 2021. pdf
Fumagalli I., Fedele M., Vergara C., Dede' L., Ippolito S., Nicolo' F., Antona C., Scrofani R., Quarteroni A.,
An Image-based Computational Hemodynamics Study of the Systolic Anterior Motion of the Mitral Valve.
Computers in Biology and Medicine, 123, 103922, 2020.
pdf
Dede' L., Regazzoni F., Vergara C., Zunino P., Guglielmo M., Scrofani R., Fusini L., Cogliati C., Pontone G., Quarteroni A. Modeling the cardiac response to hemodynamic changes associated with COVID-19: a computational study. Mathematical Biosciences and Engineering, 18(4), pp. 3364-3383, 2021. pdf
Barnafi N., Di Gregorio S., Dede' L., Zunino P., Vergara C., Quarteroni, A.,
A multiscale poromechanics model integrating myocardial perfusion and the epicardial coronary vessels.
SIAM J. Appl. Math.. 82(4), 1167--1193, 2022. pdf
Bucelli M., Dede' L., Quarteroni A., Vergara C., Partitioned and monolithic algorithms for the numerical solution
of cardiac fluid-structure interaction. Comm. Comp. Phys. 32(5), 1217-1256, 2023.
pdf
Bennati L., Vergara C., Giambruno V., Fumagalli I., Corno A.F., Quarteroni A., Puppini G., Luciani G.B., An image-based computational fluid dynamics study of mitral regurgitation in presence of prolapse. Cardiovascular Engineering and Technology, 14, 457-475, 2023 pdf
Bucelli M., Geraint Gabriel M., Quarteroni A., Gigante G., Vergara C.,
A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction. Journal of Computational Physics, 490, 112326, 2023. pdf
Quarteroni A., Dede' L., Regazzoni F., Vergara C., A mathematical model of the human heart suitable to address clinical problems.
Japan Journal of Industrial and Applied Mathematics, 40, 1547-1567, 2023. pdf
Bennati L., Giambruno V., Renzi F., Di Nicola V., Maffeis C., Puppini G., Luciani G.B., Vergara C., Turbulence and blood washout in presence of mitral regurgitation: a computational fluid-dynamics study in the complete left heart. Biomech. Model. Mechanobiol., 22, 1829-1846, 2023. pdf
Zingaro A., Vergara C., Dede' L., Regazzoni F., Quarteroni A., A comprehensive mathematical model for cardiac perfusion. Scientific Reports - Nature, 13, 14220, 2023. pdf
Renzi F., Vergara C., Fedele M., Giambruno V., Quarteroni A., Puppini G., Luciani G.B., Accurate Reconstruction of Right Heart Shape and Motion from Cine-MRI for Image-Driven Computational Hemodynamics. Int. J. Num. Meth. Biomed. Eng., 41(1), e3891, 2025. pdf .
Montino Pelagi G., Baggiano A., Regazzoni F., Fusini L., Ali' M., Pontone G., Valbusa G., Vergara C., Personalized pressure conditions and calibration for a predictive computational model of coronary and myocardial blood flow. Annals Biomed. Eng., 52, 1297-1312, 2024. pdf
Montino Pelagi G., Regazzoni F., Huyghe J.M., Baggiano A., Ali' M., Bertoluzza S., Valbusa G., Pontone G., Vergara C., Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion. Biomech. Model. Mechanobiol., 23, 1863-1888, 2024. pdf
Bennati L., Crispino A., Vergara C. Computational modeling of cardiac hemodynamics including chordae tendineae, papillaries, and valves dynamics. Computers in Biology and Medicine, 186, 109658, 2025. pdf
Renzi F., Puppini G., Luciani G.B., Vergara C. Image-based computational hemodynamics in the right heart. Biomech. Model. Mechanobiol. To appear.
pdf
Renzi F., Bennati L., Fedele M., Giambruno V., Quarteroni A., Puppini G., Luciani G.B., Vergara C., From cine-MRI to computational models of blood flow within the heart. Vascular Pharmacology, 155, 107343, 2024. pdf
Myocardial perfusion maps and coronary hemodynamics (by G. Montino Pelagi)
Cardiac hemodynamics in the right ventricle (by F. Renzi).
8) Finite Elements methods for unfitted meshes (2016-onwards)
Problem: Developing Finite Elements methods for non matching grids
Strategies: Extended Finite Elements - Discontinuos Galerkin methods for meshes with arbitrary polygons
Application: Fluid-structure interaction
Related publications :
Zonca S., Vergara C., Formaggia L., An unfitted formulation for the interaction of an incompressible fluid with a thick structure via an XFEM/DG approach.
SIAM J. Sc. Comp., 40(1), pp. B59-B84, 2018 pdf
Formaggia L., Vergara C., Zonca S., Unfitted Extended Finite Elements for composite grids. Computers and Mathematics with Applications, 76(4), pp. 893-904, 2018.
pdf
Antonietti P., Verani M., Vergara C., Zonca S., Numerical solution of fluid-structure interaction problems by means of a high order Discontinuous Galerkin method on polygonal grids. Finite Elements in Analysis and Design, 159, pp. 1-14, 2019. pdf
Vergara C., Zonca S., Extended Finite Elements method for fluid-structure interaction with an immersed thick non-linear structure. In "Mathematical and Numerical Modeling of the Cardiovascular System and Applications", SEMA SIMAI Springer Series (D. Boffi, L. Pavarino, G. Rozza, S. Scacchi, C. Vergara eds.). In press. pdf
Zonca S., Antonietti P.F., Vergara C. A Polygonal Discontinuous Galerkin formulation for contact mechanics in fluid-structure interaction problems. Comm. Comp. Phys., 30, pp. 1-33, 2021. pdf
Martinolli M., Biasetti J.,Zonca S., Polverelli L., Vergara C., Extended Finite Element Method for Fluid-Structure Interaction in Wave Membrane Blood Pumps.
Int. J. Num. Meth. Biomed. Eng., 37(7), e3467, 2021. pdf
Martinolli M., Cornat F., Vergara C.,
Computational Fluid-Structure Interaction Study of a new Wave Membrane Blood Pump.
Cardiovascular Engineering and Technology, 13, 373 392, 2022. pdf
Criseo E., Fumagalli I., Quarteroni A., Marianeschi S.M., Vergara C., Computational haemodynamics for pulmonary valve replacement by means of a reduced Fluid-Structure Interaction model. Int. J. Num. Meth. Biomed. Eng., 40(9), e3846, 2024. pdf
Fluid velocity magnitude (on the background) and structure displacement on a slice - 3D Fluid structure interaction simulation (by S. Zonca)
9) Parameter estimation for cardiovascular problems (2009-onwards)
Problem: Estimation through the solution of inverse problems of some parameters characterizing cardiovascular problems
Strategies: Minimization in a variational framework of a suitable functional. Direct search methods for application to clinical data
Applications: - Plaque characterization in carotid arteries by using CINE MRI data
- Estimation conduction velocities in cardiac electrophysiology by using activation time measures
- Calibration of cardiac perfusion model parameters
- Calibration of lumped parameter models
Related publications :
Perego M., Veneziani A., Vergara C., A variational approach for estimating the compliance of the cardiovascular tissue: An Inverse fluid-structure
interaction problem. SIAM J. Sc. Comp , 33(3), pp. 1181-1211, 2011. pdf
D'Elia M., Mirabella L.,Passerini T., Perego M., Piccinelli M., Vergara C., Veneziani A.,
Applications of variational data assimilation in computational hemodynamics, in Modeling of Physiological Flows,
Ambrosi D., Quarteroni A., Rozza G. eds., Springer, 2011.
Link
Veneziani A., Vergara C., Inverse problems in Cardiovascular Mathematics: toward patient-specific data assimilation and optimization, Editorial of the special issue "Inverse Problems in Cardiovascular Mathematics", International Journal for Numerical Methods in Biomedical Engineering, 29(7), pp. 7
23-725, 2013.
pdf
Quarteroni A., Manzoni A., Vergara C., The Cardiovascular System: Mathematical Modeling, Numerical Algorithms, Clinical Applications. Acta Numerica,
26, pp. 365-590, 2017 pdf
Quarteroni A., Dede' L., Manzoni A., Vergara C., Mathematical Modelling of the Human Cardiovascular System -
Data, Numerical Approximation, Clinical Applications, Cambridge Monographs on Applied and Computational Mathematics, Cambridge University Press, 2019. pdf
Pozzi S., Domanin M., Forzenigo L., Votta E., Zunino P., Redaelli A., Vergara C., A surrogate model for plaque modeling in carotids based on Robin conditions calibrated by cine MRI data . Int. J. Num. Meth. Biomed. Eng., 37(5), e3447, 2021. pdf
Stella S., Vergara C., Maines M., Catanzariti D., Africa P., Dematte' C., Centonze M., Nobile F., Del Greco M., Quarteroni A. Integration of activation maps of epicardial veins in computational cardiac
electrophysiology . Computers in Biology and Medicine, 127, 104047, 2020.
pdf
Di Gregorio* S., Vergara* C., Montino Pelagi G., Baggiano A., Zunino P., Guglielmo M., Fusini L., Muscogiuri G., Rossi A., Rabbat M.G., Quarteroni A., Pontone G., Prediction of myocardial blood flow under stress conditions by means of a computational model.
European Journal of Nuclear Medicine and Molecular Imaging. , 49:1894 1905, 2022.
*These authors equally contributed to the work. pdf
Vergara C., Stella S., Maines M., Africa P.C., Catanzariti D., Dematte' C., Centonze M., Nobile F., Quarteroni A., Del Greco M.,
Computational electrophysiology of the coronary sinus branches based on electroanatomical mapping for the prediction of the
latest activated region. Medical & Biological Engineering & Computing. 60, 2307 2319, 2022.
pdf
Tonini A., Regazzoni F., Salvador M., Dede' L., Scrofani R., Fusini L., Cogliati C., Pontone G., Vergara C., Quarteroni A.,
Two new calibration techniques of lumped-parameter mathematical models for the cardiovascular system. Int. J. Num. Meth. Eng., 126(1), e7648, 2025. pdf
Capuano E., Regazzoni F., Maines M., Fornara S., Locatelli V., Catanzariti D., Stella S., Nobile F., Del Greco M., Vergara C., Personalized Computational Electro-mechanics Simulations to Optimize Cardiac Resynchronization Therapy. Biomech. Model. Mechanobiol., 23, 1977-2004, 2024. pdf
Montino Pelagi G., Regazzoni F., Huyghe J.M., Baggiano A., Ali' M., Bertoluzza S., Valbusa G., Pontone G., Vergara C., Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion. Biomech. Model. Mechanobiol., 23, 1863-1888, 2024. pdf
Criseo E., Baggiano A., Montino Pelagi G., Nannini G., Redaelli A., Pontone G., Vergara C., Development of a digital twin for the diagnosis of cardiac perfusion defects, medRXiv, DOI:10.1101/2025.02.04.25321638, 2024. pdf
Characterization of tissues: plaque (yellow), jugular vein (blue, light blue and violet), healthy vessel (white) (by S. Pozzi)
10) Estimation of the flow rate in haemodynamic measures (2005-2010)
Problem: Estimation of the flow rate in vascular districts by the knowledge of the maximum velocity measured with the Doppler techniques
Strategies: Proposal of suitable laws linking the mean and the maximum valocities with parameters suitably tuned
Related publications :
Ponzini R., Vergara C., Redaelli A., Veneziani A., Reliable CFD-based estimation of flow rate in haemodynamics measures, Ultrasound in Med. and Biol., 32 (10), pp. 1545--1555, 2006. pdf
Ponzini R., Vergara C., Veneziani A., Redaelli A., Design of new reliable CFD-based estimation of flow rate in haemodynamics measures, Journal of Biomechanics (41), Supplement 1, page S214, 2008. pdf
Ponzini R., Vergara C., Veneziani A., Redaelli A., Design of new reliable CFD-based estimation of flow rate: Early in-vivo results,
Computers in Cardiology, pp. 953-955, 2008. pdf
Ponzini R., Rizzo G., Vergara C., Veneziani A., Morbiducci U., Montevecchi F.M.,
Redaelli A., Computational modeling of local hemodynamics phenomena: Methods, tools and clinical applications , Nuovo Cimento C della Societa' Italiana di Fisica - Colloquia on Physics, 32(2),
pp. 77-80, 2009
Ponzini R., Vergara C., Rizzo G., Veneziani A., Redaelli A., Vanzulli A., Parodi O.,
Computational fluid dynamics-based estimation of blood flow rate in Doppler analsys: in vivo validation
by means of phase contrast magnetic resonance imaging,
Proceedings of the ASME summer conference, pp. 227-228, 2009. pdf
Vergara C., Ponzini R., Veneziani A., Redaelli A., Neglia D., Parodi O., Womersley number-based estimation of flow rate with Doppler Ultrasound: Sensitivity analysis and first clinical application . Computer Methods and Programs in Biomedicine, 98(2), pp. 151-160, 2010.
pdf
Ponzini R., Vergara C., Rizzo G., Veneziani A., Roghi A., Vanzulli A., Parodi O., Redaelli A.,
Womersley number-based estimates of blood flow rate in Doppler analysis: In vivo validation
by means of Phase Contrast Magnetic Resonance Imaging.
IEEE Transaction on Biomedical Engineering, 57 (7), pp. 1807-1815, 2010.
pdf
Velocity profiles measured with PC-MRI. Top: abdominal aorta; Middle: carotid; Bottom: brachial artery (by R. Ponzini)
Problem: Numerical modeling of the release of drug in medical stents
Strategies: Coupling of a Darcy problem for the fluid advection and of a diffuzion-reaction problem for the drug release
Related publications :
Vergara C., Zunino P., Multiscale modeling and simulation of drug release from cardiovascular stents,
SIAM Multiscale Modeling and Simulation, 7(2), pp. 565-588, 2008. pdf
Zunino P., D'Angelo C., Petrini L., Vergara C., Capelli C., Migliavacca F. Numerical simulation of drug eluting coronary stents: mechanics, fluid dynamics and drug release . Comp. Meth. Appl. Mech. Eng.,
198(45-46), pp. 3633-3644, 2009. pdf