Person details

phone +39 02 2399 3173
email arianna.rossetti@polimi.it
keyboard_voice Voip Call
location_on V. MANCINELLI 7, 20131 MILANO
web Polimi Personal Page
group OrganicSCM Lab

Education and training
2014-2018: Ph.D. in Industrial Chemistry and Chemical Engineering, Politecnico di Milano (Italy)
Febr. - July 2016: Visiting Ph.D. student at Prof. Dr. A.S.S. Doemling’s research group - Drug Design Lab, Groningen University (NL)
Dec. 2014: National qualification to practise as a Pharmacist (Italy)
July 2014: Master’s Degree in Medicinal Chemistry and Pharmaceutical Technology, Università degli Studi di Milano (Italy)

Previous positions
2018 – 2021: Post-doctoral fellowship at Chemistry, Material and Chemical Engineering Department "Giulio Natta" (CMIC), Politecnico di Milano (Italy)
Febr. – April 2018: Research fellowship by INSTM at Chemistry, Material and Chemical Engineering Department "Giulio Natta" (CMIC), Politecnico di Milano (Italy)
2016 – 2017: R&D researcher, medicinal chemist at TelesisPharma B.V. laboratories by UMCG University of Groningen (NL)

Research interests
My research interests range from organic synthesis, especially applied to scaffolds with a pharmaceutical interest, to coordination polymers and catalysis, with a particular attention to the bispidinic core. In parallel, I am working on nanoparticles synthesis, hydrogel modifications, biopolymers and biobased materials functionalizations, in different fields of nanomedicine.


Scientific publications

1. Book chapter: “Metal-organic frameworks (MOFs) for sensing” in “Advances in Chemical Engineering” Sacchetti, A.; Rossetti, A.; Martí-Rujas, J. 2021, Elsevier, in press, ISSN 0065-2377, (DOI:10.1016/bs.ache.2021.03.002)

2. Review: “Synthesis of Natural Compounds Based on the [3,7]-Diazabicyclo[3.3.1]nonane (Bispidine) Core” Sacchetti, A.; Rossetti, A. J. Org. Chem. 2021, 10, 1491–1507. (DOI: 10.1002/ejoc.202001439)

3. Review: “Advances in bio-based polymers for colorectal cancer treatment: Hydrogels and nanoplatforms” Maspes, A.; Pizzetti, F.; Rossetti, A.; Makvandi, P.; Sitia, G.; Rossi, Gels 2021, 7 (1), 6, 1-28. (DOI: 10.3390/gels7010006)

4. Paper: “Effect of surface decoration on properties and drug release ability of nanogels” Pinelli, F.; Pizzetti, F.; Rossetti, A.; Posel, Z.; Masi, M.; Sacchetti, A.; Posocco, P.; Rossi, F. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2021, 614, (DOI: 10.1016/j.colsurfa.2021.126164)

5. Paper: “Functionalized nanogel for treating activated astrocytes in spinal cord injury” Papa, S.; Veneruso, V.; Mauri, E.; Cremonesi, G.; Mingaj, X.; Mariani, A.; De Paola, M.; Rossetti, A.; Sacchetti, A.; Rossi, F.; Forloni, G.; Veglianese, P. Journal of Controlled Release 2021, 330, 218-228. (DOI: 10.1016/j.jconrel.2020.12.006)

6. Paper: “Lipase-Catalyzed Kinetic Resolution of Alcohols as Intermediates for the Synthesis of Heart Rate Reducing Agent Ivabradine” Morandini, A.; Rossetti, A.*; Sacchetti, A. Catalysts 2021, 11, 53, 1-10. (DOI: 10.3390/catal11010053)

7. Paper: “3D integration of pH-cleavable drug-hydrogel conjugates on magnetically driven smart microtransporters” Bernasconi, R.; Mauri, E.; Rossetti, A.; Rimondo, S.; Suriano, R.; Levi, M.; Sacchetti, A.; Pané, S.; Magagnin, L.; Rossi, F. Materials and Design 2021, 197,109212. (DOI: 10.1016/j.matdes.2020.109212)

8. Paper: “Plasmonic control of drug release efficiency in agarose gel loaded with gold nanoparticle assemblies” Moretti, L.; Mazzanti, A.; Rossetti, A.; Schirato, A.; Polito, L.; Pizzetti, F.; Sacchetti, A.; Cerullo, G.; Della Valle, G.; Rossi, F.; Maiuri, M. Nanophotonics 2021, 10 (1), 247-257. (DOI: 10.1515/nanoph-2020-0418)

9. Paper: “Electrodeposition of Tin onto Zinc for the Electrochemical Synthesis of Zn/Sn/Cu Precursor Stack for CZTS-Based Photoconversion Devices” Panzeri, G.; Dell'Oro, R.; Castelli, F.; Rossetti, A.; Rossi, F.; Magagnin, L. ChemElectroChem 2020, 7 (19), 4084-4092. (DOI: 10.1002/celc.202001152)

10. Paper: “Influence of the core formulation on features and drug delivery ability of carbamate-based nanogels” Pinelli, F.; Pizzetti, F.; Ortolà, Ó.F.; Marchetti, A.; Rossetti, A.; Sacchetti, A.; Rossi, F. Int. J. Mol. Sci. 2020, 21 (18), 6621, 1-15. (DOI: 10.3390/ijms21186621)

11. Paper: “Selective modulation of A1 astrocytes by drug-loaded nano-structured gel in spinal cord injury” Vismara, I.; Papa, S.; Veneruso, V.; Mauri, E.; Mariani, A.; De Paola, M.; Affatato, R.; Rossetti, A.; Sponchioni, M.; Moscatelli, D.; Sacchetti, A.; Rossi, F.; Forloni, G.; Veglianese, P. ACS Nano 2020, 14 (1), 360-371. (DOI: 10.1021/acsnano.9b05579)

12. Paper: “Synthesis and characterization of carbomer-based hydrogels for drug delivery applications” Rossetti, A.; Pizzetti, F.; Rossi, F.; Mauri, E.; Borghi, E.; Ottaviano, E.; Sacchetti, A. International Journal of Polymeric Materials and Polymeric Biomaterials, 2020, in press. (DOI: 10.1080/00914037.2020.1760275)

13. Paper: “Ester coupling of ibuprofen in hydrogel matrix: A facile one-step strategy for controlled anti-inflammatory drug release” Mauri, E.; Rossetti, A.; Mozetic, P.; Schiavon, C.; Sacchetti, A.; Rainer, A.; Rossi, F. Eur J Pharm Biopharm. 2020, 146, 143-149. (DOI: 10.1016/j.ejpb.2019.11.002)

14. Paper: “Effects of primary amine-based coatings on microglia internalization of nanogels” Mauri, E.; Veglianese, P.; Papa, S.; Rossetti, A.; De Paola, M.; Mariani, A.; Posel, Z.; Posocco, P.; Sacchetti, A.; Rossi, F. Colloids Surfaces B Biointerfaces. 2020, 185. (DOI: 10.1016/j.colsurfb.2019.110574)

15. Paper: “Design of polymer-based antimicrobial hydrogels through physico-chemical transition” Mauri, E.; Naso, D.; Rossetti, A.; Borghi, E.; Ottaviano; E.; Griffini, G.; Masi, M.; Sacchetti, A.; Rossi, F., Materials Science and Engineering: C, 2019,103, 109791. (DOI: 10.1016/j.msec.2019.109791)

16. Paper: "Synthesis and antimicrobial evaluation of novel chiral 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives " Rossetti, A.; Bono, N.; Candiani, G.; Meneghetti, F.; Roda, G.; Sacchetti, A., Chem. Biodiversity, 2019, 16 (6), e1900097. (DOI: 10.1002/cbdv.201900097)

17. Paper: "Highly Dynamic and Tunable Behavior of 1D Coordination Polymers Based on the Bispidine Ligand" Rossetti, A.; Lippi, M.; Martí-Rujas, J.; Sacchetti, A.; Cametti, M., Chem. Eur. J. 2018, 24, 1 – 6. (DOI: 10.1002/chem.201804782)

18. Paper: "Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(II)-catalyzed asymmetric Henry reaction" Rossetti, A.; Landoni, S.; Meneghetti, F.; Castellano, C.; Mori, M.; Colombo Dugoni, G.; Sacchetti, A. New J.Chem., 2018, 42, 12072-12081. (DOI: 10.1039/c8nj01930d)

19. Paper: “Microwave-assisted synthesis of TEMPO-labeled hydrogels traceable with MRI” Mauri, E.; Micotti, E.; Rossetti, A.; Melone, L.; Papa, S.; Azzolini, G.; Rimondo, S.; Veglianese, P.; Punta, C.; Rossi, F.; Sacchetti, A. Soft Matter 2018, 14, 558-565. (DOI: 10.1039/c7sm02292a)

20. Paper: "Rapid access to reverse turn peptidomimetics by a 3C-Ugi reaction on 3,4-dihydroisoquinoline." Rossetti, A.; Sacchetti, A; Gatti, M.; Pugliese, A.; Roda, G. Chem. Heterocycl. Compd. 2017, 53 (11), 1214–1219. (DOI 10.1007/s10593-018-2202-5)

21. Paper: “Ugi MCR-Based Synthesis of Medium-Sized Rings” Abdelraheem, E.; Dömling, A.; Madhavachary, R.; Rossetti, A.; Shaabani, S.; Kurpiewska, K.; Kalinowska-Tłuścik, Org. Lett., 2017, 19 (22), 6176–6179. (DOI: 10.1021/acs.orglett.7b03094)

22. Communication:”Two-Steps Synthesis of Complex Artificial Macrocyclic Compounds”, Rudrakshula, M.; Abdelraheem, E.; Rossetti, A.; Twarda-Clapa, A.; Musielak, B.; Kurpiewska, K.; Kalinowska-Tłuścik, J.; Holak, T.; Dömling, A. Angew. Chem. Int. Ed. 2017, 56, 10725-10729. (International Edition: DOI: 10.1002/anie.201704426)

23. Paper: “Biocatalysed olefin reduction of 3-alkylidene oxindoles by baker's yeast” Rossetti, A.; Sacchetti, A.; Bonfanti, M.; Roda, G.; Rainoldi, G.; Silvani, A. Tetrahedron, 2017, 73, 4584-4590. (DOI: 10.1016/j.tet.2017.06.022)

24. Paper: "Facile Synthesis of N-Substituted Benzimidazoles" Kurhade, S.; Rossetti, A.; Dömling, A., Synthesis, 2016, 48 (21), 3713-3718. (DOI: 10.1055/s-0035-1562436)

25. Paper: "Hydrogel supported chiral imidazolidinone for organocatalytic enantioselective reduction of olefins in water" Sacchetti, A.; Rossi, F.; Rossetti, A.; Mauri E.; Pesa, R. Chemical Papers, 2016, 70 (4), 436–444. (DOI: 10.1515/chempap-2015-0232)