Nano-probes to enable more effective diagnosis

A study conducted by Politecnico di Milano, CNR, IRCCS Istituti Clinici Scientifici Maugeri and IRCCS Ospedale San Raffaele has been published in the prestigious «Journal of the American Chemical Society» (JACS); the researchers have developed a new type of fluorinated nano-probe that allows cellular activity to be visualised at different levels of resolution by combining magnetic resonance imaging and Raman microscopy.

Having a single probe that can be recorded both in vivo through MRI and, in greater detail, in tissues and within target cells through Raman microscopy, may soon make it possible to follow the pathway of a drug in precise detail from the site of administration to the individual cell.

The research, which involved researchers from the Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” and Department of Physics of the Politecnico, is part of the NEWMED project, funded by the Lombardy Regional Government, which aims to introduce new approaches to nanomedicine and photonics in the clinical setting.

A Bioorthogonal Probe for Multiscale Imaging by 19F-MRI and Raman Microscopy: From Whole Body to Single Cells

Cristina Chirizzi, Carlo Morasso, Alessandro Aldo Caldarone, Matteo Tommasini, Fabio Corsi, Linda Chaabane, Renzo Vanna, Francesca Baldelli Bombelli, and Pierangelo Metrangolo

https://doi.org/10.1021/jacs.1c05250

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